This paper examines the role of wireless handheld devices in the Pakistani healthcare environment using a quantitative approach. This study identifies a list of barriers and drivers, and a factor analysis of the qualitative data identifies that key determinants such as “technology management”, data management”, “improved outcome”, “efficiency”, and “application limitations” were concerned with the usage of wireless handheld devices in the Pakistani healthcare environment. The results of the study are further analysed through regression analysis, on the basis of factor analysis. The results for the regression analysis indicate that for the dependent factor “intention to use” with independent factors, “technology management”, data management”, “improved outcomes”, “efficiency”, and “software applications” the value for the adjusted r-square was 0.524 and p value was 0.00. A total of 300 surveys were distributed, 97 useable surveys were returned, and the data was analysed through the SPSS software.